SrasV1, Main, Exploration, bibRecord, 006398

Glycyrrhizin, an active component of liquorice roots, and replication of SARS-associated coronavirus

Identifieur interne : 006398 ( Main/Exploration ); précédent : 006397; suivant : 006399

Glycyrrhizin, an active component of liquorice roots, and replication of SARS-associated coronavirus

Auteurs : J. Cinatl [Allemagne] ; B. Morgenstern [Allemagne] ; G. Bauer [Allemagne] ; P. Chandra [Allemagne] ; H. Rabenau [Allemagne] ; H. W. Doerr [Allemagne]

Source :

Lancet : (British edition) [ 0140-6736 ] ; 2003.

RBID : Pascal:03-0401367

Descripteurs français

Pascal (Inist)
- Appareil respiratoire pathologie, Aigu, Coronavirus, Antiviral, Activité biologique, Homme, SRAS.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Acute, Antiviral, Biological activity, Coronavirus, Human, Respiratory disease.

Abstract

The outbreak of SARS warrants the search for antiviral compounds to treat the disease. At present, no specific treatment has been identified for SARS-associated coronavirus infection. We assessed the antiviral potential of ribavirin, 6-azaurldine, pyrazofurin, mycophenolic acid, and glycyrrhlzin against two clinical Isolates of coronavirus (FFM-1 and FFM-2) from patients with SARS admitted to the clinical centre of Frankfurt University, Germany. Of all the compounds, glycyrrhlzin was the most active In inhibiting replication of the SARS-associated virus. Our findings suggest that glycyrrhlzin should be assessed for treatment of SARS.

Affiliations:

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: 000969
to stream PascalFrancis, to step Curation: 000022
to stream PascalFrancis, to step Checkpoint: 000961
to stream Main, to step Merge: 006910
to stream Main, to step Curation: 006398

Le document en format XML

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<front><div type="abstract" xml:lang="en">The outbreak of SARS warrants the search for antiviral compounds to treat the disease. At present, no specific treatment has been identified for SARS-associated coronavirus infection. We assessed the antiviral potential of ribavirin, 6-azaurldine, pyrazofurin, mycophenolic acid, and glycyrrhlzin against two clinical Isolates of coronavirus (FFM-1 and FFM-2) from patients with SARS admitted to the clinical centre of Frankfurt University, Germany. Of all the compounds, glycyrrhlzin was the most active In inhibiting replication of the SARS-associated virus. Our findings suggest that glycyrrhlzin should be assessed for treatment of SARS.</div>
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Glycyrrhizin, an active component of liquorice roots, and replication of SARS-associated coronavirus

Glycyrrhizin, an active component of liquorice roots, and replication of SARS-associated coronavirus

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri